FlyMAD (Fly Mind Altering Device) is a system for targeting freely
walking flies (Drosophila) with lasers. By steering the optical path
of the laser using large diameter mirrors, it also enables
simultaneous imaging of the target region. This enables
through-the-mirrors (TTM) targeting of specific body parts. Together,
all this allows rapid thermo- and opto- genetic manipulation of the
fly nervous system.
The work is published in:
Bath DE✱, Stowers JR✱, Hörmann D, Poehlmann A, Dickson BJ, Straw AD
(✱ equal contribution) (2014) FlyMAD: Rapid thermogenetic control of
neuronal activity in freely-walking Drosophila. Nature
Methods. doi 10.1038/nmeth.2973
See our video. This is a slightly modified version of Supplementary Video S1.
An installer for FlyMAD is available here. This requires
Ubuntu 12.04 amd64.
Please address all enquires to the FlyMAD email list.
FlyMAD is open source. Access our repository on github.
FlyMAD was supported by the Natural Sciences and Engineering Research
Council of Canada by a postgraduate scholarship to Daniel Bath, ERC
Starting Grant 281884 and WWTF grant CS2011-029 to Andrew Straw, ERC
Advanced Grant 233306 to Barry Dickson and IMP core funding.